Experimental study of the effects of steroids (MPS and MPA) frequently applied into the knee joint on the articular cartilage

Abstract

Recently various steroids have been used focal or systemic in rheumatoid arthritis, osteoarthritis and allergic or other collagenic diseases. In this study, we have investigated the histopathological effects of MPA long term-affected and MPS short term affected on the articular cartilage of the knee joint of 32 adult New Zeland. According to the steroids that we have used, were observed weight loss, marked osteoporosis in the surroundings of the knee joint. Grossly sparced dark yellow areas of the articular cartilage, microscopycally the thinning of the cartilage, the diminish in number, degeneration and necrosis of chondrocytes, the formation of the cyst and the microcyst within the matrix, the production of the fibrous tissue around the cyst, the thinning of the subchondral trabeculae. The pathological change in the right knee joint after being given steroids were found more evident than those in the left knee ioint injected salin. It has been seen that these pathological changes have significantiy increased progressively as related to the period. The dosage and the frequency of the steroids. It has also noticed that these lesions have significantiy produced in the left knee joint iniected salin as related to the period and the dosage of steroids. The lesions thot MPS has caused were more less than those of MPA and they were equally in each two knee joint. Consequently we have determined experimentaliy that the given steroidsiocal intra-articular or systemic, have resulted in the progressively increasing death and degeneration of the chondrocytes, the formation of the cyst and the microcyst within the matrix, the production of the fibrous tissue around the cyst and the thinning of the cartilage and the subchondral trabeculae as reiated to the period, the dosage and the frequency of the steroids.