Experimental study of negative pressure wound therapy combined with platelet-rich fibrin for bone-exposed wounds.

Abstract

Aim: To evaluate the efficacy of negative pressure wound therapy (NPWT) combined with platelet-rich fibrin (PRF) in treating bone-exposed wounds and explore its possible mechanism. Materials & methods: Abone-exposed wound was created in a total of 32healthy Sprague-Dawley rats, which were divided into either control group, NPWT group, PRF groupor both (N+P group). The bone-exposed area, skin contraction rateand granulation coverage and the level of growth factors in granulation tissue were determined on days 4, 7and 10. Results: The N+P group showed significantly higher wound closure rate than that achieved with others respectively. Four factors were significantly higher in N+P group than in the other three groups. Conclusion: Combination of NPWT and PRF can repair bone-exposed wounds effectively and accelerate wound healing.