Abstract
Background: This is still a public problem that needs to be solved urgently: chronic and refractory wound healing with long course and complex pathological mechanism. At present, there is still a lack of effective clinical treatment. This study, therefore, aims at exploring moist exposed burn therapy/moist exposed burn ointment (MEBT/MEBO) combined with Zhuang medicine detoxification in the treatment of chronic refractory wound healing. Methodology: 100 SPF Wistar rats were randomly divided into blank control group, model control group, MEBO group, Zhuang medicine group and Combined group, with 20 rats in each group. Open wound model was established in blank control group, and chronic refractory wound model was established in other groups. Black control group and model control group were given food and water freely, MEBO group was given dressing change once a day, Zhuang medicine group was given intragastric administration once a day, and combined group was given dressing change and intragastric administration once a day. The effective rate of wound healing was observed after 12 days of continuous intervention. Conclusion: Skin regeneration medical technique combined with Zhuang medicine poison theory can effectively reduce the symptoms of bleeding and exudation, reduce the area of wound, shorten the healing time of wound, and achieve physiological healing of wound. It has a good effect on chronic refractory wound.
Highlights
Chronic non-healing wounds on the surface of the body usually refer to the disease course of more than 1 month, unable to achieve anatomic and functional integrity through the normal orderly and timely repair process, and the condition is complex and changeable [1]
Blank control group and model control group and normal breeding, Moist exposed burn ointment (MEBO) group according to the handbook of burn skin regeneration medical technology clinical methods described daily switching time, Zhuang medicine group according to the experimental animals and human equivalent dose conversion method described the dose of 3200 mg/kg/d Zhuang medicine decoction lavage daily once, joint group used at the same time treatment and drug lavage once a day
There were differences in wound healing efficiency among all groups (χ2 = 50.953, P < 0.001), there was no difference between the combined group and the blank control group (Z = 1.310, P = 0.190), but there were differences between the combined group and the MEBO group (Z = −3.072, P = 0.002), and between the combined group and the Zhuang medicine group (Z = −2.934, P = 0.003)
Summary
Chronic non-healing wounds on the surface of the body usually refer to the disease course of more than 1 month, unable to achieve anatomic and functional integrity through the normal orderly and timely repair process, and the condition is complex and changeable [1]. With the improvement of the etiology and prevention and control techniques of chronic nonhealing wounds, the diagnosis and treatment techniques are gradually diversified, among which the moist exposed burn therapy/moist exposed burn ointment (MEBT/MEBO) is a relatively mature technology for the prevention and treatment of chronic nonhealing wounds At present, it is widely used in clinical treatment of diabetic foot, pressure ulcers, venous ulcer, nerve ulcer and other diseases, and has achieved good efficacy in alleviating wound pain, promoting wound healing, reducing scar formation rate and amputation rate after healing [2]. The treatment principle and mode of MEBO/MEBT are in line with the syndrome differentiation and treatment of TCM external treatment, which can accelerate wound healing and affect cell proliferation, differentiation and metabolic function in the process of wound repair This is still a public problem that needs to be solved urgently: chronic and refractory wound healing with long course and complex pathological mechanism.
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