Experimental study of interaction between galanthamine and mouse brain acetylcholinesterase in vivo

Abstract

Injection of armin into mice after preliminary administration of galanthamine leads to a decrease in the inhibition of brain acetylcholinesterase (ACE) induced by the reversible inhibitor. This effect is associated with the accumulation of acetylcholine and displacement of galanthamine by it from the active centers of ACE. In experiments in vivo, the competitive character of interaction between galanthamine and ACE was thus revealed.