Abstract

Since ketosis is the combined result of metabolic disturbances and hormonal effects, our investigation was concerned with the determination of the levels of ketone bodies, glucose, and FFA in the blood of intact dogs before and after the administration of thyroid and growth hormone, and of dogs whose pancreas, thyroid or pituitary had been removed, either singly or in various combinations. Because of pathophysiological considerations and of the information provided by a number of AA. the influence of the thyroid on ketonemia was of particular interest. The following findings were made: the blood levels of ketone bodies, glucose, and FFA increased most after pancreatectomy; exogenous thyroid hormone had no significant effect on these blood levels; thyroidectomy did not contribute in decreasing ketone bodies, glucose, and FFA in blood, or at the most to an insignificant degree and differently according to the prevailing condition. Possibly, thyroid hormones potentiate the action of STH which participates in the formation of ketone bodies.

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