Abstract
The initial observation that the pituitary gland varies in size and histologic structure during pregnancy was first reported in 1899 by Comte (1), who described a hypertrophy and hyperplasia in the human hypophysis. Other investigators, Launois and Mulon (2), Mayer (3), Alin (4). and Biedl (5), on human material, agree with the classical observations of Erdheim and Stumme (6), namely, that during pregnancy the gland increases in size. In addition, the latter maintained that while in the nullipara the chief cells or chromophobes are less abundant than the chromophilie cells, during pregnancy an increase in the number of chief cells occurs with a simultaneous change in their histologic character to such an extent that they should be spoken of as a new cell-type, the pregnancy cell (Schwangerschaftszelle). Biederman (7) decided that they are weakly basophilic. After termination of pregnancy, an involution of the pregnancy cells occurs, and they revert back, for the most part, to their old structure.
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