Abstract
ABSTRACT The salient features of chronic ulcerative colitis are a continuous or intermittent intractable, bloody diarrhea, and sometimes abdominal pain, anemia, fever and general debility. The inflammation of the colon is evidenced by a hyperemic and edematous, granular, easily bleeding mucous membrane or profuse exudate covering the lining, and, later, superficial and deep ulceration. The ulcers for the most part are confluent and shaggy, with indefinite borders and with no special point of origin in the mucosa. The infection begins in the rectum and lower colon, and progresses upward to the cecum, sometimes invading the lower ileum. It may remain localized in the rectosigmoid region for months or years.The disease was first mentioned by Wilks and Moxon,1 in 1875, but was first described by White,2 in 1888, although Hawkins 3 believes that the pedigree of this disease can be traced back nearly three hundred years in the 'bloody
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