Abstract
This work presents a continuous Heck coupling reaction combined with organic solvent nanofiltration (OSN) separation of the catalyst in situ, using polymeric membranes at high temperature (80°C) and high concentration of base (>0.9molL−1). Two reactor configurations are investigated: a continuous single stirred tank reactor/membrane separator (m-CSTR) and a plug flow reactor (PFR) followed by m-CSTR (PFR–m-CSTR). The combined PFR–m-CSTR configuration was found to be the most promising, achieving conversions above 98% and high catalyst turnover numbers (TONs) of ∼20,000. In addition, low contamination of the product stream (∼27mgPdperkg of product) makes this process configuration attractive for the pharmaceutical industry.
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