Abstract
The pathogenesis of experimental mastitis in the mouse was determined by histopathological, ultrastructural and bacteriological examination of the mammary glands of mice at various times after the intramammary inoculation of a strain of Staphylococcus aureus of high virulence. In this system the critical point was the interaction of staphylococci and neutrophils between 12 and 18 h. after inoculation of staphylococci. In the majority of mice the neutrophils did not succeed in containing the staphylococci, there was rapid extracellular multiplication in the alveolar lumen, toxin production, coagulative necrosis and some mortality 24 to 48 h. after inoculation.
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