Experimental solubility measurement of cephalexin in supercritical carbon dioxide

Abstract

In recent years, using supercritical carbon dioxide for different chemical processes in particular particle micronization has been surprisingly increased. Knowing the substance solubility in supercritical solvent is a critical parameter during the particle size reduction processes. In this direction, solubility of cephalexin was measured in the supercritical carbon dioxide by changing the temperature and pressure between 308.15 K to 338.15 K and 16 Mpa to 40 MPa, respectively. The measured solubility of cephalexin in supercritical carbon dioxide was in the range of 1.13×10-5 to 4.89 ×10-3 based on the mole fraction at the different operational condition. Besides the experimentally measurement of cephalexin solubility, modeling of the results using four commonly used correlations namely Mendez-Santiago and Teja (MST), Bartle, Kumar and Johnston and Chrastil models were performed. The results revealed that the Chrastil model is the most accurate used semi-empirical correlation in the present study with the lowest average absolute relative deviation percent of (AARD %) of 9.43 %.