Abstract
AbstractAn experimental model in mice was investigated to test the hypothesis that the immunohistochemical findings in skin lesions of human systemic lupus erythematosus (SLE) might be due to circulating antibody reacting with nuclear antigens. Mice were immunized with ultraviolet (UV)‐irradiated DNA to produce high titers of circulating antibody to a DNA photoproduct, thymine dimer. These immunized mice were then whole‐body irradiated with UV, a procedure which caused thymine dimer formation in DNA of skin cells and subsequent release of thymine dimers extracellularly during spontaneous repair of the photochemically damaged DNA. In immunized irradiated mice, immunofluorescent studies showed fixation of mouse Ig and complement in the form of finely stippled and large lumpy deposits in the dermal—epidermal areas and in nuclei of epidermal cells. These findings were morphologically quite similar to those seen in human SLE skin lesions. These immunohistochemical lesions in mice were not observed in mice receiving only immunization or only irradiation. These and other data lend support to the immune complex theory of pathogenesis of SLE skin lesions.
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