Abstract
A temperature-sensitive filamentous mutant of Salmonella enteritidis administered orally to 1-day-old chicks exhibited the same predilection for the caudal intestine and ceca as the wild type of the organism. Administered intracardially, it was found by 6 hr postinoculation (PI) in the cecal lumen but was unable to proliferate there and by 24 hr PI declined slowly in numbers. Rare fragments of the filaments were seen in the lower intestinal and cecal epithelium and lamina propria, but no true entry into the tissues appeared to occur. By 24 hr following intracardial inoculation in 1-day-old chicks, the blood and liver cultured negative. Clearance was even more rapid in 2-week-old birds inoculated intravenously. The organism produced no observable pathological changes in any tissue of either age group apart from a mild heterophil response in the ceca of 1-day-old chicks following oral administration.
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