Abstract
Objective To investigate the effect of long-term intraocular retention of Perfluorodecalin （PFDL） on tissue and electrophysiological characteristics of rabbit ocular tissue, and to explore its pathogenesis. Methods Thirty-two health rabbits were observed and different amount of PFDL were injected into anterior chamber and vitreous cavity, 6, 24 and 72 hours, 7, 30 and 60 days after operation, cornea and retina were evaluated by transmission electron microscopy, specular microscope and electrophysiological examination.Results From 24 hours to 7 days after operation, oedema in cells were detected; 30 and 60days after operation, loss of endothelial cells was significantly, amplitudes of b waves were reduced significantly; cornea showed necrosis in epithelium and stroma; Dilation and degranulation of endoplasmic reticulum, Degeneration, atrophy and necrosis in photoreceptor cell, oedma occurred between cells and in nerve fibers. Myeline figure were observed in retinal photoreceptor and corneal endothelium. Conelusions There are detrimental effects of PFDL to cornea and retina 24 hours after intraocular retention, and the mechanism seems to be related to gravity, free radical and destruction of energy metabolism, we would not recommend it to be used as an long time intraocular tamponade. Key words: Perfluorodecalin/toxicity; Retina/drug action; Cornea/drug action
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
