Experimental reproduction of respiratory mold allergy

Abstract

1. In an effort to evaluate clinical mold sensitivity, 22 patients reacting to Alternariawere subjected to a mold room test with powdered Allernaria. Half of them developed hay fever or asthma (Table V). 2. Ten of 12 patients whose histories suggested mold allergy gave a positive mold room test, while only one of 10 doubtful mold cases developed a positive mold room test with Alternaria. 3. When powdered Alternaria was blown directly into the noses of patients reacting to Alternaria, 10 of 12 clinically positive mold cases reacted, but only one positive and one questionable positive reaction were obtained of 17 so-called doubtful mold cases. 4. A typical mold history probably indicates true clinical mold sensitivity in the presence of a positive scratch test. 5. The nasal test with Alternaria is simple, and if done outside the mold season, is a safe and reliable means of evaluating Alternaria sensitivity. 6. An interesting parallel between a positive scratch test to Alternaria and inhalation tests by either the nasal or mold room method is noted. 7. These experiments demonstrate the importance of Alternaria as an allergen.