Abstract
Groups of bonnet monkeys (Macaca radiata) were experimentally infected with the three serotypes of reoviruses. Reovirus types 1 and 2 induced the production of high levels of homotypic hemagglutination-inhibiting antibody in all monkeys and, in addition, heterotypic antibodies to the other two serotypes in some. Type 3 virus induced only homotypic antibody response. A second infection with type 3 virus also induced only a homotypic response. In monkeys previously infected with reovirus type 2, type 3 infection caused a fourfold or greater rise in type 3 antibody but no enhancement of type 1 or 2 antibody. In monkeys previously infected with reovirus type 3, type 2 infection induced the production of antibodies reactive to types 1 and 2 in some, but no rise of type 3 antibody in any. In monkeys previously infected with type 1, type 3 infection induced a fourfold or greater rise in antibody to all three serotypes. Among those previously infected with type 3, type 1 infection caused an enhancement of antibodies to types 1 and 3 in all and to type 2 in a few.
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