Abstract
SummaryThe effect of preliminary renal ischemia produced by bilateral renal artery occlusion for 2, 4, 5 and 6 hours on subsequent experimental renal hypertension production on 19 dogs has been studied. In general the results suggest that previous renal damage of both a mild and severe degree has an effect on experimental renal hypertension. Seven dogs receiving mild renal injury showed a very high rise in mean arterial pressure in the first month following bilateral renal artery constriction, and a subsequent fall in pressure to near normotensive levels. The 4 dogs that survived more severe renal damage showed slight to no rise in mean arterial pressure during the first 3 or more months following bilateral renal artery constriction. The dogs of this group which were observed for more than three months showed an abrupt rise in mean arterial pressure, one 3 months and the other 51/2 months after bilateral renal artery constriction.
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