Abstract
The initial interaction between uroepithelial cells and Escherichia coli which has adhesive or invasive activity for cultured cells was studied ultrastructurally at the in situ site of infection in the model of ascending pyelonephritis in mice. The densely piliated adhesive strain E77156 isolated from the urine of a patient with urinary tract infection adhered to the pelvic and renal tubular epithelial cells and colonized on their cell surfaces and thereafter in the cytoplasm. The non‐piliated invasive strain 633–65 isolated from a patient with dysentery‐like syndrome did not colonize on the uroepithelial cell surfaces but easily penetrated into the cytoplasm of these cells. Thereafter multiplication was observed in their cytoplasm. Neither strain scarcely penetrated into the interstitium via the basement membrane of the renal tubules.
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