Experimental Production of Glandular Cystic Hyperplasia of Endometrium with Estrogenic Substances of Parturient Urine

Abstract

In a recent review of the important gynecological condition of glandular cystic hyperplasia of the endometrium, attention was called to the wide divergence of opinion concerning the amount of estrogenic substance necessary to produce it.1 The enormous proliferation of the endometrium and the finding of increased amounts of an estrous inducing substance in the blood and urine of a certain percentage of these cases point to an excessive production of estrogenic hormones, as a result the disease is commonly referred to as an hyperestral one, or is said to exhibit hyperestrinism. Evans,2 Novak,3 Siebke,4 Zondek,5 Frank,6 Kurzrok7 and Fluhmann8 all seem to favor this view. On the other hand the occurrence of the disease in sterile women, its close relation to amenorrhea and its occurrence near the menopause and after partial castration indicate that there is a decreased function of the ovary and a lowered ovarian secretion. Seitz9 and Mazer and Goldstein10 have taken this latter view.Due to the rapidly changin...