Experimental periodontitis and peri‐implantitis in dogs

Abstract

To analyze the tissue reactions following ligature removal in experimental periodontitis and peri-implantitis in dogs. Four implants with similar geometry and with two different surface characteristics (turned/TiUnite Nobel BioCare AB, Göteborg) were placed pair-wise in a randomized order in the right side of the mandible 3months after tooth extraction in 5 dogs. Experimental peri-implantitis and periodontitis were initiated 3months later by ligature placement around implants and mandibular premolars and plaque formation. The ligatures were removed after 10weeks, and block biopsies were obtained and prepared for histological analysis 6months later. It was demonstrated that the amount of bone loss that occurred during the period following ligature removal was significantly larger at implants with a modified surface than at implants with a turned surface and at teeth. The histological analysis revealed that peri-implantitis sites exhibited inflammatory cell infiltrates that were larger, extended closer to the bone crest and contained larger proportions of neutrophil granulocytes and osteoclasts than in periodontitis. It is suggested that lesions produced in experimental periodontitis, and peri-implantitis are different and that implant surface characteristics influence the inflammatory process in experimental peri-implantitis and the magnitude of the resulting tissue destruction.