Abstract
Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay.
Highlights
Transmissible spongiform encephalopathies (TSEs), known as prion diseases, are a group of fatal neurologic diseases caused by a misfolded form of the prion protein (PrPSc)
We report the preliminary findings of an ongoing multiyear study
The oronasal susceptibility of sheep to the agent of Chronic wasting disease (CWD) is a major finding in light of its possible effect on risk assessment and understanding possible transmission of CWD to noncervid species in field conditions
Summary
We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Another similarity between scrapie and CWD is prominent lymphoid accumulation of PrPSc in both species affected [5]. The Study Initially, we oronasally inoculated [9] seven Suffolk lambs (3–4 months of age) with the V136R154Q171/ARQ (n = 2), ARQ/ARQ (n = 4), or ARQ/ARR (n = 1) prion protein genotype and 0.1 g of 10% (wt/vol) brain homogenate from a GG96 white-tailed deer that had CWD. We used a Emerging Infectious Diseases www.cdc.gov/eid Vol 27, No 12, December 2021
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