Abstract
Claude S. Beck and others have pioneered work indicating that temporary augmentation of the coronary circulation is possible by producing adhesions between the myocardium and pericardium. As yet, however, no satisfactory simple method of producing these adhesions has been evolved. Experiments have been performed upon 227 rats to determine the efficiency of substances that might be injected into the pericardial sac and thereby furnish collateral extracoronary blood supply. Experiments have also been performed to determine the effect of adhesions upon the relative physical efficiency of the normal rat and of the rat subjected to ligation of the left coronary artery. Various concentrations of thirteen different detergents and six miscellaneous .agents were placed in the pericardial sac of the rat. Five per cent monoethanolamine oleate proved to be the most efficacious and nontoxic of the agents tried, producing good vascular adhesions without complications. These adhesions did not affect the efficiency of normal rats. Ligation of the left coronary artery of normal rats diminished their physical efficiency. Production of adhesions soon after ligation of the left coronary artery had little beneficial effect.
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