Abstract
We provide the first experimental evidence for resonance Raman optical activity (RROA). In non-aqueous solution (+)-naproxen ((S)-6-methoxy-α-naphthalenacetic acid) and its deuterated methyl ester exhibit monosignate negative RROA, whereas the RROA spectrum of (−)-naproxen sodium is monosignate positive (aqueous solution above pH 10), for 514 nm excitation. In all cases, the RROA bands exhibit the same relative intensities as those in the parent resonance Raman (RR) spectrum, and the ratio of RROA to RR is comparable in magnitude, but opposite in sign, to the electronic circular dichroism (CD) anisotropy ratio of the lowest energy electronic state near 330 nm. These findings are in accord with the theory of RROA in the limit of strong resonance with a single electronic state.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
