Abstract
Female New Zealand White rabbits were inoculated with increasing numbers of infective Obeliscoides cuniculi larvae. The results of the experiment indicate that many similarities exist between the infection produced by this gastric nematode of rabbits and Trichostrongylus or Ostertagia infections of cattle and sheep. An acute postinoculation phase produced by larval activity was the most striking clinical effect. Length of the prepatent period and severity of the acute phase were directly related to the size of the larval inoculum. Egg production and the percentage of inoculum recovered at autopsy were inversely proportional to the number of larvae administered. The number of adult parasites present in the stomach was constant irrespective of the number of infective larvae given. Dysproteinemia, anemia, diarrhea, or peripheral edema were not produced. The associated pathological changes were primarily those of a gastritis, the main lesion being a coarsely granular mucosa overlying thickened, edematous fundic rugae. Ulceration (often with hemorrhage into the lumen of the stomach), petechiation, and the appearance of small white foci in the mucosa were noted. Uses for the model in the laboratory study of ruminant trichostrongylidosis are suggested.
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