Abstract
Methods and results Male Lewis rats (n=11) were subjected to myosin immunization and developed autoimmune myocarditis. Approximately 3 weeks later, rats with myocarditis underwent CMR scan and subsequently, histopathological evaluation. Rats with myocarditis showed pericardial thickening, effusion, and LV wall motion abnormalities with septal hypokinesis. Short axis views showed patchy delayed enhancement of epicardial segments, with distribution mainly located within the inferolateral LV wall including the septum. This increased signal/hyperenhancement defines focal areas of myocardial fibrosis/ edema and/or necrosis, highly suggestive of inflammation. Additionally, the presence of large pericardial effusion provides supportive evidence for the existence of perimyocarditis. Indeed, high correlation was found
Highlights
We aimed to compare cardiac magnetic resonance (CMR) imaging, using a clinical whole body 3T system, with histopathological measurement and 2D echocardiography as a method for the quantitative evaluation of the extent of myocardial involvement and function in a rat model of autoimmune myocarditis
Short axis views showed patchy delayed enhancement of epicardial segments, with distribution mainly located within the inferolateral LV wall including the septum
High correlation was found between CMR examination and echocardiography (Figure 1)
Summary
Shunit Rinkevich-Shop1*, Natalie Landa-Rouben, Fred Epstein, Tamar Ben-Mordechai, Arnon Afek, Micha S Feinberg, Orly Goitein, Eli Konen, Tammar Kushnir, Jonathan Leor. From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011
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