Abstract
The capacity of myocardium, acutely injured in vivo by ischemia, to maintain cell volume regulation in vitro was studied in dogs with posterior papillary muscle infarcts of 60 and 120 min duration. Non-ischemic control tissue maintained mean K + concentrations of about two thirds of the K + found in left ventricular myocardium in vivo and had tissue H 2O volumes which were virtually identical to those observed in vivo. The extracellular space of the control slices was greater than that estimated to be present in vivo. The slices of irreversibly-injured ischemic tissue were greatly swollen, showed low K + and Mg 2+ and often exhibited structural defects in the plasma membrane of the sarcolemma. In addition, damaged tissue showed a significantly increased inulin diffusible space after 60 and a greater diffusible space after 120 min of ischemia. These findings are new evidence indicating that increased myocardial cell membrane permeability is an early feature of irreversible ischemic injury.
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