Abstract
Results The i.v. and i.n. challenged mice showed significant DTH response. The CFU enumeration in eye did not show any bacilli initially by 30th day however tubercle bacilli could be recovered from the eyes of i.v. infected mice by 45 day at the time of death. Histopathology of these eyes showed inflammation with cluster of lymphocytes. The RTPCR for IS6110 gene from the eyes of i.n. infected animals was positive at different doses whereas i.v. challenged mice showed variability. Furthermore, the cytokine analysis in infected tissue supernatants of both eyes and lung showed high Th1 response (IFN-g) in comparison to non-infected group.
Highlights
Tuberculous uveitis is one of the emerging forms of extrapulmonary tuberculosis
understand the many unknown facets of this disease pertaining to diagnosis
histopathological studies and cytokine analysis were performed in these animals
Summary
Tuberculous uveitis is one of the emerging forms of extrapulmonary tuberculosis. To understand the many unknown facets of this disease pertaining to diagnosis, treatment and pathogenesis, a mouse model of tuberculous uveitis was established.
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