Abstract
In addition to the harmful effect of albendazole on parasites, it is necessary to take into account the toxic effect of this drug on the body.The purpose of the study. Determine an effective therapeutic dose of albendazole that does not have a toxic effect.Material and methods of research. To study the albendazole effect in various dosages on the formation of the echinococcal cyst (bladder), experiments were conducted on sheep (8 sheep) artificially infected with echinococcosis. To determine the effect of albendazole, liver tissues of sheep subjected to and not subjected to chemotherapy were studied.Results of the study. A comparative study of the emerging embryonic blisters of sheep treated and not treated with albendazole showed a significant difference in the dynamics of the formation of embryonic blisters.Conclusion. Albendazole in a dose of 5 mg / kg of weight affects the fatal effect on the embryonic form of echinococcus and is an effective therapeutic dose without toxic effect in the prevention of echinococcosis relapse.
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