Experimental modification of the pH value of the synovial fluid of rabbits. Gas analysis studies

Abstract

After the intraarticular injection of isoosmolalic acid (pH 5.0) or alkaline (pH 10.0) buffer solutions into the right knee joints and physiological buffer solution (pH 7.3) into the left side (control) of rabbits are aspirated samples of synovial fluid during a period of 90-120 minutes. The pH value, carbondioxid tension (pCO2) and oxygen tension (pO2) are determinated with an Astrup-equipment. The injection of an acid or alkaline buffer solution is followed immediately by a decrease or increase of the pH value. During a period of 60-70 minutes is continuously reached the physiological pH level. The repeated injections of an acid buffer solution don't cause an adaptation effect to the pH 'overloading'. The pH value and pCO2 have a reciprocal relationship.