Experimental models of arthritis: Identification of substance P as a therapeutic target and use of capsaicin to manage joint pain and inflammation

Abstract

Substance P (SP) is involved with the induction of arthritic pain and inflammation. A structural basis for these effects is provided by the expression of SP receptors on peripheral neurons and leukocytes. Effects of SP on inflammatory responses are modulated by other neuropeptides such as calcitonin gene-related peptide (CGRP, often coreleased with SP or enkephalins), which have central as well as peripheral antinociceptive functions. Capsaicin, a compound with established analgesic effects, has been used extensively as a pharmacological tool to study the role of SP in experimental models of inflammatory arthritis. Research further supports the role of SP in the pathogenesis of arthritis and suggests that capsaicin may be considered a novel agent with both antinociceptive and antiinflammatory properties.