Abstract
Histamine is an important mediator released from activated mast cells in acute bronchoconstriction provoked by allergen, exercise, hypertonic stimuli and inhaled adenosine. Histamine may also contribute to the allergen-induced late asthmatic response probably following the recruitment and activation of basophils. H1-receptor antagonists partially attenuate these responses but greater inhibition when these drugs are combined with cysteinyl LT1-receptor antagonists indicative of an interaction between mast cell-derived mediators. The combination of two or more selective mediator antagonists in the treatment of allergic disorders such as asthma offers a new therapeutic approach worthy of careful appraisal.
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