Abstract
The paper discusses the known model of the atherosclerotic process in laboratory animals and cell cultures. Unfortunately, playing in the experiment all the complexity of the interaction of etiological and pathogenesis mechanisms of atherosclerosis remains inaccessible for the modern researcher, primarily due to species differences in human and experimental animals. Opportunities and limitations of laboratory animals to study etiology and pathogenesis of atherosclerosis have been analysed.The authors suggest the experimental model of atherosclerosis, based on the blocking fat cells and heparin (protamine sulfate within 21 days against a background of the alimentary hyperlipidemia), which allowed to oppress activity of lipoprotein lipase of blood, and substantially increase the frequency and severity of atherosclerosis in rats. Today, a wide range of animal models and cell cultures allows you to choose for each specific purpose of the study the most adequate model of playback of one or another level of pathogenesis.On one hand, significant progress in the technique of clinical research of pathogenesis of atherosclerosis largely brings their possibilities to the terms of the experiment, and on the other hand - modeling the individual elements in the pathogenesis is more preferable for analytical purposes.
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