EXPERIMENTAL MODELING AND FUTURE DIRECTIONS OF HOMEOSTASIS CORRECTION IN INFLAMMATORY BOWEL DISEASES

Abstract

Inflammatory bowel disease (IBD) - Crohn’s disease (CD) and ulcerative colitis (UC) are chronic diseases with an unknown etiology and pathogenesis. The medical treatment of such pathologies causes lots of adverse effects and usually doesn’t lead to the persistent remission. Studying of an etiology and pathogenesis, improvement of methods of treatment of IBD dictates need of adequate experimental modeling of UC and CD. The purpose of the article is to make an analysis of the literature, indexed in Pubmed, Medline, Russian Science Citation Index, dedicated to the IBD modeling and perspective ways of homeostasis correction during such pathologies as CD and UC. The oxazo-lone injection was determined as the most optimal way of UC modeling and the injection of trinitrobenzensulfonic acid (TNBS) for CD modeling. Economical and clinical benefits of oxazolone and TNBS usage, the results of clinical and preclinical studies and adverse events of Aloe vera, Boswellia serrata, Trigonella foenum-graecum, Andrographis paniculata, omega 3 fatty acids, Ulmus fulva, Potentilla erecta, liquorice, coenzyme Q10, vitamin B12, Cucruma longa and vitamin D are described in the analyzed literature. The critical literature analysis gives us an ability to distinguish vitamin D and Cucruma longa as perspective therapeutic agents for the development of the pharmaceuticals with anti-inflammatory, immunomodulatory and composite antioxidant effects, for UC and CDs’ treatment, causing the minimum of adverse effects. Suppositories were determined as the most optimal and perspective dosage form, used for the IBD treatment, according to the best biofarmaceutical features among the other forms.