Abstract
BackgroundTo evaluate the benefits of lutein in preventing retinal phototoxicity generated by xenon light sources during vitreoretinal surgery.MethodsA prospective cross-sectional study in pigmented rabbit eyes exposed to different vitreoretinal surgery lighting simulations. Twenty Dutch-belted rabbits were divided into two groups exposed to two different xenon wavelength light sources filters (420 nm and 435 nm). In addition, two subgroups were administered with daily supplemental of 10 mg of Lutein systemically. Electroretinography (ERG), optical coherence tomography (OCT) and fluorescein angiography (FA) were performed before and after surgery to quantify the retinal damage.ResultsAll animals submitted to the experiment presented some degree of phototoxicity independent of wavelength light filter used. Retinal damage was evident as the FA presented areas of hyperfluorescence, and the OCT depicted increased reflective areas of the inner and outer retinal layers, and RPE. ERG showed a diffuse reduction of the a and b waves amplitudes in all animals.ConclusionUse of systemic administration of lutein showed no benefit to avoiding retinal phototoxicity generate to xenon light source using filters of 435 nm and 420 nm when comparing to the control group.
Highlights
To evaluate the benefits of lutein in preventing retinal phototoxicity generated by xenon light sources during vitreoretinal surgery
The macular pigment functions as a filter that absorbs short wavelengths of visible light, reducing chromatic aberration and dispersion in the
We evaluated the benefits of supplemental lutein in preventing retinal phototoxicity generated by light sources for vitreoretinal surgery simulations in pigmented rabbits using two wavelengths (420 nm and 435 nm)
Summary
To evaluate the benefits of lutein in preventing retinal phototoxicity generated by xenon light sources during vitreoretinal surgery. The eye is constantly exposed to sunlight and artificial light, which is essential for its biological functions such as vision and regulation of the circadian rhythm. When the exposure to light is excessive, radiation may generate visual impairment and even blindness [1]. The use of an intraocular illumination is necessary, increasing light exposure to the vitreous, retina and subretinal space [2]. Four types of Teixeira et al Int J Retin Vitr (2019) 5:11 the retina with 30 min of light exposure. Lutein and Zeaxanthin are carotenoids present in the macular retinal pigment. The macular pigment functions as a filter that absorbs short wavelengths of visible light, reducing chromatic aberration and dispersion in the. Filtration of short wave helps in preventing photochemical damage to cones and EPR [7,8,9,10]
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