Abstract
The aim of the study, performed on 65 Wistar rats, was to develop a new model and, as an example, use it to identify the extent to which quercetin and the quercetin-2-hydroxypropyl-β-cyclodextrin nanocomplex, applied to the wound, affect the engraftment of skin autografts. Grafts were obtained from the ear shells of animals, and graft’s survival rate was assessed by the degree of inhibition of wound contraction. It is shown that the latter depends on the area of grafts and the time after which they were located on the wound surface after its creation. It was shown that quercetin worsens, and quercetin-2- hydroxypropyl-β-cyclodextrin does not impair the ability of the wound surface to accept the graft.
Highlights
Grafts were obtained from the ear shells of animals
graft's survival rate was assessed by the degree of inhibition
It is shown that the latter depends on the area
Summary
A. Experimental model for assessing the readiness of the wound surface to accept skin grafts. У жывёл другой серыі (n = 20) вывучалі інгібіраванне кантракцыі раны (ІКР) ва ўмовах пераносу ТТ рознай плошчы на РП. Апошні раз вобласць былой раны фатаграфавалі праз 100 сут пасля АТ.
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More From: Proceedings of the National Academy of Sciences of Belarus, Medical series
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