Abstract
For the first time, the solubilities of sertraline hydrochloride in SC-CO2, as a binary system, and SC-CO2 + menthol, as a ternary system, were determined. Experimental data was achieved at 308, 318, 328 and 338 K at different pressures ranging from 12 to 30 MPa. The solubility of sertraline in the binary system was found to range from 0.100 × 10−5 to 0.930 × 10−4 mole fractions, while that in the ternary system exhibited solubility values between 0.61 × 10−4 and 0.89 × 10−3 mole fractions, indicating the significant effect of adding menthol on the solubility of sertraline in SC-CO2. In addition, the solubility of sertraline in both systems was correlated to empirical and semiempirical density-based models. The solubility results from this research would be helpful in the selection of supercritical fluid method for production of sertraline nanoparticles.
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