Abstract
Flufenamic acid (FFA) is a BCS II class drug having low solubility and high permeability in the gastrointestinal tract. The solubility enhancement techniques of BCS II class drugs such as co-crystallization, solid dispersion or fine particle generation by supercritical or liquid antisolvent method require the knowledge of solubility of API in the organic solvent. In the present work, the equilibrium solubility of FFA was determined in methanol, ethanol, 1-propanol and 2-propanol at a temperature ranging from 298 to 318 K. Different models such as the modified Apelblat equation, λh equation, NRTL and Wilson were used to correlate the experimental solubility of FFA in these solvents. The enthalpy of mixing (ΔmH), entropy of mixing (ΔmS) and Gibbs energy of mixing (ΔmG) were computed in the real binary mixture of FFA – solvent to examine the nature of mixing thermodynamically.
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