Abstract

An experimental lens-induced granulomatous endophthalmitis (ELGE), which histopathologically is virtually identical to the human phakoanaphylactic endophthalmitis (or lens-induced uveitis), was produced after injury to the lens in rats that had been previously sensitized to homologous lens protein in complete Freund's adjuvant. ELGE was not observed in four different groups of control animals. We believe, therefore, that this study provides direct evidence that ELGE is an immune reaction to autologous lens antigens in rats previously sensitized to homologous lens antigens.

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