Experimental investigation and modeling of the solubility of oxcarbazepine (an anticonvulsant agent) in supercritical carbon dioxide

Abstract

To produce micro- or nano-sized particles of a solid solute drug, it is necessary to investigate their solubility behavior in supercritical carbon dioxide (SC-CO2). In this study, for the first time, solubility of Oxcarbazepine (as anticonvulsant agent) in SC-CO2 was determined using static method. For this purpose, experiments were performed at different operating temperatures (308–338 K) and pressures (120–270 bar), and feasible molar solubilities were found to range from 1.100 × 10−7 to 2.675 × 10−5. Three different groups of methods were applied to correlate the solubility data of Oxcarbazepine, including (1) two equations of state (EoSs), namely Peng-Robinson (PR) and PRSV equation of state (vdW2 mixing rules), (2) six density-based semi-empirical models, namely Sodeifian et al., Chrastil, Bartle et al., Garlapati et al., Méndez-Santiago and Teja (MST), and Kumar and Johnston (K-J), and (3) Wilson's model. Statistical analysis of the results revealed superiority of Peng-Robinson model over the other models. Experimental data consistency was performed on various semi empirical models. Finally, the approximate values of total (ΔHtotal), vaporization (ΔHvap), and solvation (ΔHsol) enthalpies were calculated for OXC.