Abstract
ABSTRACT The perfluorocarbon liquids (PFCLs) are a group of compounds with a specific gravity greater than water that are used as an adjunct in the surgical management of complicated vitreoretinal diseases. Thirty-two pigmented rabbits underwent vitrectomy with injection of one of three PFCLs or saline into the vitreous cavity: eight eyes received perfluorotributylamine (PFTA); eight eyes received perfluorodecaline (PFDC); eight eyes received perfluoropolyether (PFPE); the remaining eight eyes, which served as controls, received saline. One hour after placement in the eyes the PFCLs were removed from the vitreous cavity and the eyes were filled with saline. The rabbits were then euthanized and the eyes enucleated and processed for histologic examination. Light microscopy demonstrated no significant difference between eyes with the PfCLs compared with those of control animais. Electron microscopy revealed only minor changes, consisting of a few irregulary shaped defects in the outer segment discs of photoreceptors, in the PFDC group only. These findings suggest that short-term intraoperative use of PFTA, PFPE, and PFDC, at least in this experimental animal model, is not associated with any significant retinal pathology.
Highlights
From the Doheny Eye Institute, and the Department of Ophthalmology, University of Southem Califomia School of Medicine, Los Angeles, Califomia
Silicone oil is most widely used as a vitreous substitute, there are some problems with its use and controversy over its possible toxicity continues(l-S)_ ln addition, silicone oil has a low specific gravity, and is not of benefit in the repair of inferior breaks or for intraoperative management of complicated retinal detachments(9, I O)
Liquid perfluorochemicals meet many of the criteria that are desirable in a vitreous substitute, and several have been tested as potential vitreous substitutes(I I-IS)
Summary
Silicone oil is most widely used as a vitreous substitute, there are some problems with its use and controversy over its possible toxicity continues(l-S)_ ln addition, silicone oil has a low specific gravity, and is not of benefit in the repair of inferior breaks or for intraoperative management of complicated retinal detachments(9, I O). Recent1y CHANG and coworkers
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