Abstract
✓ Intracerebral hematoma was simulated in 16 dogs. Oxygen tension was measured in the adjacent cerebral parenchyma, fourth ventricle, and cervical subarachnoid space by both microelectrode and sampling techniques in the course of four different studies. Determinations of intracranial pressure and the pH, pO2, pCO2 of arterial blood and cerebrospinal fluid (CSF) were made. Reductions of oxygen tension were encountered uniformly, both in brain parenchyma and CSF, following the induction of intracerebral hematoma. There was an associated acidosis in the CSF compartment. The findings cannot be explained on the basis of increased intracranial pressure or reduced cerebral perfusion. The acidosis may be related to the metabolic effects of blood as well as tissue hypoxia. The changes suggest additional reasons for the evacuation of intracerebral hematomas in man.
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