Abstract
The combined effect of Candida albicans, a facultative pathogen in the normal physiological condition in the throat of miners, and amosite dust produces after intratracheal inoculation extensive collagenous fibrosis at 330 days in rhesus monkeys. The lesions produced by amosite dust alone comprise fine reticulin fibrosis around bronchioles and blood vessels and moderate interstitial fibrosis. The C. albicans infection alone caused acute inflammatory reaction in the early stages while at the termination of experiment (330 days) the only evidence of pulmonary candidiasis was a few small fibrotic foci of compactly arranged reticulin fibers.
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