Abstract
Intraperitoneal inoculation of adult mice with mouse adenovirus caused a generalized infection with occasional deaths. Virus was found widely distributed in several tissues as well as in white blood cells from the third day after inoculation. L cells were used for viral recovery and assay. The highest viral titers were reached in the spleen. No virus was detected in tissues and white blood cells after 2 weeks. In contrast, virus was demonstrated in the urine by the 14th day and viruria persisted for as long as 2 years. A similar picture was found after intranasal inoculation. The failure to demonstrate virus in tissues after the early weeks of infection was probably due to the production of high levels of antibody for up to 2 years.
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