Abstract
IgA mesangial deposits are commonly associated with IgA-IgG nephropathy (Berger's disease) and anaphylactoid purpura. Since it has been demonstrated that orally administered ferritin induces specific IgA anti-ferritin antibody in mice, we studied the effects of orally administered ferritin on renal structure and immunohistology in four groups of adult Swiss Webster mice. Group I received ferritin (1mg/ml) in drinking water for 30 days. Group II received the same plus 20 mg Ferritin IP on day 29. Group III received only 20 mg of Ferritin IP 24 hours before sacrifice. Group IV were normal adult mice. Animals were sacrificed on day 30. Immunohistology revealed granular deposits of IgA in the mesangium of 9/11 animals in Group I; 7 of the animals in this group showed IgG, 6 C3, and 1 fibrinogen in a similar pattern. In Group II lmmunoglobulin deposition was similar, but less pronounced. One animal in Group III showed IgA but no IgG or C3. None of the animals in Group IV showed immunohistologic changes. Light microscopy changes were not significant in any group. EM on selected specimens from Group I showed abundant mesangial, paramesangial, and subendothelial electron dense deposits as well as ferritin-like particles. These preliminary studies suggest a role for oral sensitization in nephropathy characterized by predominant IgA deposition and provides an experimental animal model of IgA mesangial deposit disease.
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