Abstract
By feeding under conditions of reduced oxygen supply, the increase in serum, arterial, and brain tissue levels of lipid peroxide in rats was prompted. The arterial-tissue level of lipid peroxide increased with advancing hypoxia, but the brain and serum levels of lipid peroxide were elevated at 2-weeks feeding under conditions of reduced oxygen supply and restored to the values obtained before the onset of the experiment at 4 weeks. In the liver, lipid peroxides due to hypoxia were only slightly increased in liver-tissue level of lipid peroxide. It was indicated by these observations that the possibility exists that hypoxia might be one of the factors predisposing to the accumulation of lipid peroxide, and that peroxidation might occur not only in conditions of excessive supply of oxygen but also in conditions of short supply of oxygen.
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