Abstract
In experimental hypertensive rats (DOCA-implantation, 1% saline as drinking-water, encapsulation of the left kidney), the norepinephrine turnover in peripheral sympathetically innervated organs and the central nervous system was determined either by the decay in endogenous norepinephrine after inhibition of tyrosine hydroxylase or by the ecayd in the specific norepinephrine activity after intravenous or intraventricular administration of3H-norepinephrine. In the heart, the norepinephrine turnover was accelerated in proportion to the rise in blood pressure. In hypothalamus and medulla oblongata, the turnover was delayed reciprocally to the acceleration in the heart. No changes were seen in the residual parts of the brain.
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