Abstract
Difficulties in approbation of drugs for the treatment of vestibular dysfunction are associated with a lack of knowledge of the mechanisms of its development. In particular, it is necessary to take into account the initial state of the vestibular analyzer, which significantly affects the research results. Therefore, the modeling of pathological processes that manifest in vestibular dysfunction is the optimal method for studying both its mechanisms and the effectiveness of medications for its relief. Endolymphatic hydrops is found in most diseases manifested by peripheral vestibular syndrome. We have proposed several models of endolymphatic hydrops in rats to study various aspects of its pathogenesis and approbate means of treating vestibular dysfunction.
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