Abstract
Abstract Hydralazine hydrochloride (Apresoline), a vasodilator drug used in treatment of arterial hypertension, was orally administered to eight apparently healthy normotensive dogs in an attempt to reproduce the collagen-like syndrome found in man as a delayed toxic reaction to this drug. Doses approximated the maximum used in treatment of human arterial hypertension. The animals developed a syndrome manifested by weakness, weight loss, anemia, and altered electrophoretic patterns of serum proteins; leukopenia, hyperglobulinemia, and hypocholesterolemia occurred in one or more. The L-E cell was demonstrated in the peripheral blood by special techniques in seven animals and hematoxylin bodies in the other. Pathologic specimens of the kidneys revealed changes consistent with those found in disseminated lupus erythematosus.
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