Experimental Hookworm Infection in Laboratory animals: Parasite behavior, Immune response and Chemotherapeutic Studies

Mahendra K Bhopale

doi:10.31579/2766-2314/040

Abstract

Hookworm disease is known to be caused allergic manifestation and severe anemic pathogenicity in man and canine hosts. Attempts have been made to establish laboratory models of Necator americaus, Ancylostoma duodenale, and Ancylostoma ceylanicum, together with canine parasite, Ancylostoma caninum. The studies include pathophysiological aspects of the host-parasite relationship, and develop to establish patent infection. Immunological approach to selecting antigen for diagnosis and protective immunity purpose using larval and adult worm antigens and their secretions became the focus with the subsequent discovery of cloning in vaccine development as main research interest. Chemotherapy of newer drug screening in laboratory models ultimately selected to use for preventive chemotherapy in hookworm endemic areas using recommended drugs.

Highlights

The incidence of intestinal helminthiasis, especially hookworm disease is alarmingly high in tropical and sub-tropical countries [1, 2]
Human and canine hookworm models established in laboratory animals representing N. americanus, A. ceylanicum and A. caninum infection to study parasite behavior, immune response and chemotherapeutical evaluation of newer drugs
Protective immune response was observed in the host on repeated larval infections and passive transferring sensitized immune cells in A. caninum infection in mice

Summary

Introduction

The incidence of intestinal helminthiasis, especially hookworm disease is alarmingly high in tropical and sub-tropical countries [1, 2]. Recombinant polypeptide belonging to the Ancylostoma secreted protein (ASP)-1 family has shown promising results of reducing hookworm burdens after larval challenge infection in mice [31]. Irradiated larval vaccine: Earlier, a highly effective vaccine was developed to control A. caninum infection in dogs immunized with Xirradiated A. caninum L3, protected against subsequent challenge with normal larvae [32].

Results

Conclusion