Abstract
Herpetic encephalitis may be produced in rabbits by inoculating such animals either subdurally, intravenously, subcutaneously, or intraperitoneally. The possibility of inducing herpetic encephalitis in guinea pigs by feeding occurred to us. While there is little evidence to support the view that epidemic encephalitis in man is caused by the herpes virus, any evidence regarding the portals of entry of this virus into the animal body is important. Nothing is known concerning the portal of entry of the true virus of epidemic encephalitis and epidemiological control of the disease is based largely upon speculation. It is known that paralysis follows the inoculation of the virus of poliomyelitis into the stomach and intestines of monkeys and it seemed probable to us that infection might be produced in this way with the herpes virus.Four guinea pigs were fed by catheter 3 cc. of a freshly prepared emulsion of herpetic (Beckley) rabbit brain. One guinea pig received 4 cc. while a 6th received 5 cc. Of the 6 guin...
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