Abstract
Mother rats were treated daily with 30,000 USP units of vitamin A on the 8th, 9th and 10th days of gestation. Subsequently, some of them were given 1 % aqueous solution of thiourea as drinking water from the 15th to the 22nd day of gestation. Autopsy was performed on the 22nd day of gestation. Maternal hy- pervitaminosis A often induced exencephaly in fetuses in which the diencephalon including the hypothalamus was degenerated, but the an- terior pituitary persisted. Thiourea caused con- spicuous goiter to the same extent both in exencephalies and in non-exencephalies. The ob- servations suggest that the formation of goiter in fetuses is independent of the fetal hypothala- mus. A possibility of maternal TRF as a stim- ulator of pituitary-thyroid function in the fetal rat must also be considered. (Endocrinology 88: 261,1971)
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